Polarization spectroscopy methods in the determination of interactions of small molecules with nucleic acids – tutorial

• Tamara Šmidlehner,
• Ivo Piantanida and
• Gennaro Pescitelli

Beilstein J. Org. Chem. 2018, 14, 84–105, doi:10.3762/bjoc.14.5

• ) of a chiral molecule can be determined [37]. Furthermore, an oligonucleotide VCD spectrum calculation was described recently [38]. 5.1. DNA VCD In VCD spectroscopy, two major spectral regions can be monitored to probe the structures of nucleic acids. In the region between 1700–1600 cm−1, the

Characterization of the synthetic cannabinoid MDMB-CHMCZCA

• Carina Weber,
• Stefan Pusch,
• Dieter Schollmeyer,
• Sascha Münster-Müller,
• Michael Pütz and
• Till Opatz

Beilstein J. Org. Chem. 2016, 12, 2808–2815, doi:10.3762/bjoc.12.279

• – Toxicology, Äppelallee 45, 65203 Wiesbaden, Germany 10.3762/bjoc.12.279 Abstract The synthetic cannabinoid MDMB-CHMCZCA was characterized by various spectroscopic techniques including NMR spectroscopy and tandem mass spectrometry. The synthetic sample was found to be of S-configuration by VCD spectroscopy

• cannabinoids; VCD spectroscopy; Introduction Starting in 2008 with the appearance of “Spice products”, herbal mixtures spiked with synthetic cannabinoid receptor agonists began to spread on the international drug market [1][2]. The cannabimimetic substances are the psychoactive ingredients of those mixtures

• ) by VCD spectroscopy and comparison with DFT calculations. Thus, the readily available (S)-tert-leucine would be a starting material for the synthesis of (S)-3. ECD spectroscopy was inferior to VCD in this case. The enantiomeric purity of material from five test purchases and three police seizures